Crystallization is an important unit operation in the manufacture of a wide range of chemicals - from bulk chemicals, such as fertilizers through high-added value products, such as the latest pharmaceutical blockbuster drug.
A well-designed crystallization process will give the desired yield, purity, and particle size distribution.
The METTLER TOLEDO suite of advanced crystallization tools are used to:
The nature of a crystallization process is governed by both thermodynamic and kinetic factors, which can make it highly variable and difficult to control. Factors such as impurity level, mixing regime, vessel design, cooling profile, and anti-solvent addition rate can have a major impact on the size, number, and shape of crystals produced.
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METTLER TOLEDO works closely with our customers to ensure they receive the maximum benefits offered by our advanced Process Analytical Technology (PAT), including:
- FBRM® for in-process particle measurement of the rate and degree of change in the number, dimension, and shape of crystals; After purchasing Lasentec® in 2001, METTLER TOLEDO has become the world leader for inline particle system characterization
- PVM® for real-time particle and droplet imaging and understanding
- ReactIRTM FT-IR spectroscopy for in situ reaction monitoring and control of relative supersaturation
- Automated Lab Reactors for precise monitoring and control of the critical process variables in the crystallization step.
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